PREvention of Complications to Improve OUtcome in elderly patients with acute Stroke

Stroke is the world’s second largest cause of death and the third cause of long-term disability. The annual costs for stroke care in Europe are currently estimated at € 64.1 billion. Elderly patients have a high risk of complications after stroke, such as infections or fever. These complications are strongly associated with a higher risk of death or dependency. Currently, they are treated only after their occurrence.


The PRECIOUS project seeks to find out whether a pharmacological strategy to prevent these complications can reduce the risk of death or long-term disability. PRECIOUS will recruit 3800 patients in 80 hospitals to the study. Patients aged 66 years or older will be randomised to a strategy to prevent complications in the first four days of their hospitalisation, or to standard care. This simple and generally available treatment strategy has the potential to lead to an annual reduction of over 25,000 elderly Europeans being dead or dependent as a result of stroke, at very low costs.


For download


undefinedStudy Protocol


undefinedInformed Consent Forms


undefinedSummary Card

Randomisation and eCRF

mRS & NIHSS Training Resource


PRECIOUS Partners Coordinator: University Medical Center Utrecht University of Nottingham Oslo universitetssykehus HF ASST di Mantova University of Debrecen ECRIN Erasmus MC University Medical Center Institute of Psychiatry and Neurology Tartu University Hospital University of Glasgow University of Edinburgh Universitätsklinikum Hamburg-Eppendorf Academic Medical Center CTC North University of Thessaly Stroke Alliance for Europe ARTTIC

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